# GLP-1 Drugs May Raise Fragility Fracture Risk in Older Adults With T2D

**URL:** <https://indianmedforum.org/t/glp-1-drugs-may-raise-fragility-fracture-risk-in-older-adults-with-t2d/26>\
**Category:** Medicine\
**Tags:** research\
**Created:** [February 25, 2026, 7:31pm UTC](https://indianmedforum.org/t/glp-1-drugs-may-raise-fragility-fracture-risk-in-older-adults-with-t2d/26 "2026-02-25T19:31:26Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![jsx](https://indianmedforum.org/user_avatar/indianmedforum.org/jsx/32/217_2.png) [@jsx](https://indianmedforum.org/u/jsx)\
**Post date:** [February 25, 2026, 7:31pm UTC](https://indianmedforum.org/t/glp-1-drugs-may-raise-fragility-fracture-risk-in-older-adults-with-t2d/26/1 "2026-02-25T19:31:26Z")

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> In older adults with type 2 diabetes (T2D), the initiation of GLP-1 receptor agonists vs drugs such as DPP-4 and SGLT2 inhibitors was associated with an 11% increased risk for fragility fractures.
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> Overall, 4086 new incidences of fragility fractures were recorded over 147,250 person-years, with femur fractures being the most common, accounting for 26.7% of the fractures that occurred first.
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> The increased risk for fractures was significant among individuals aged 65-75 years (HR, 1.26; _P_ \< .001) but not among those aged 75 years or older.

> **[GLP-1 Drugs May Raise Fracture Risk in Older Adults With T2D](https://www.medscape.com/viewarticle/glp-1-drugs-may-raise-fragility-fracture-risk-older-adults-2026a10005o4)**
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> GLP-1 therapy is linked to an increased risk for fragility fractures among older adults with type 2 diabetes.